科研项目
1. 2021.01-2025.12，山东大学杰出中青年学者学科建设经费
2. 2020.01-2024.12，微生物进化改造技术开发及抗逆元件挖掘，国家重点研发计划子课题
3. 2020.01-2023.12，大肠杆菌中D-2-羟基戊二酸分解代谢机制研究，国家自然科学基金面上项目
4. 2019.01-2020.12，代谢工程改造产酸克雷伯氏菌高效生产丙酮酸，山东省重点研发计划
5. 2019.01-2023.12，山东大学齐鲁青年学者学科建设经费
6. 2018.04-2021.06，微生物2-羟基羧酸分解代谢的应用基础研究，山东省杰出青年基金
7. 2015.01-2018.12，恶臭假单胞菌中一条新的戊二酸代谢途径，国家自然科学基金面上项目
8. 2014.07-2016.12，赖氨酸生物转化生产5-氨基戊酸，国家高技术研究发展计划
9. 2013.01-2016.12，新型NAD非依赖性D-乳酸脱氢酶催化机理及应用基础研究，国家自然科学基金面上项目
10. 2012.11-2015.12，2-丁醇工程菌的基因组规模系统代谢育种，国家高技术研究发展计划
11. 2015.07-2020.06，铜绿假单胞菌L-乳酸代谢关键酶调控机制，山东大学青年学者未来计划
代表性论文
1. Zhang Manman, Kang Zhaoqi, Guo Xiaoting, Guo Shiting, Xiao Dan, Liu Yidong, Ma Cuiqing, Xu Ping,Gao Chao*. Regulation of glutarate catabolism by GntR family regulator CsiR and LysR family regulator GcdR inPseudomonas putida KT2440.mBio. 2019, 10, e01570-19
2. Li Zhong, Yan Jinxin, Sun Jinkai, Xu Ping, Ma Cuiqing,Gao Chao*. Production of value-added chemicals from glycerol using in vitro enzymatic cascades.Commu. Chem. 2018, 1, 71
3. Guo Xiaoting, Zhang Manman, Cao Menghao, Zhang Wen, Kang Zhaoqi, Xu Ping, Ma Cuiqing,Gao Chao*, D-2-Hydroxyglutarate dehydrogenase plays a dual role in L-serine biosynthesis and D-malate utilization in the bacteriumPseudomonas stutzeri.J. Biol. Chem.2018, 293, 15513–15523
4. Zhang Manman,Gao Chao*, Guo Xiaoting, Guo Shiting, Kang Zhaoqi, Xiao Dan, Yan Jinxin, Zhang Wen, Tao Fei, Dong Wenyue, Liu Pan, Yang Chen, Ma Cuiqing, Xu Ping*, Increased glutarate production by blocking the glutaryl-CoA dehydrogenation pathway and a catabolic pathway involving L-2-hydroxyglutarate.Nat. Commu. 2018, 9, 2114.
5. Zhang Wen, Zhang Manman,Gao Chao*, Zhang Yipeng, Ge Yongsheng, Guo Shiting, Guo Xiaoting, Zhou Zikang, Liu Qiuyuan, Zhang Yingxin, Ma Cuiqing, Tao Fei, Xu Ping*, Coupling between D-3-phosphoglycerate dehydrogenase and D-2-hydroxyglutarate dehydrogenase drives bacterial L-serine synthesis.Proc Natl Acad Sci U S A. 2017, 114, E7574-E7582.
6. Jiang Tianyi, Guo Xiaoting, Yan Jinxin, Zhang Yingxin, Wang Yujiao, Zhang Manman, Sheng Binbin, Ma Cuiqing, Xu Ping,Gao Chao*, A bacterial multidomain NAD-independent D-lactate dehydrogenase utilizes flavin adenine dinucleotide and Fe-S clusters as cofactors and quinone as an electron acceptor for D-lactate oxidization.J. Bacteriol. 2017, 199, e00342-17.
7. Li Zhong, Zhang Manman, Jiang Tongtong, Sheng Binbin, Ma Cuiqing, Xu Ping,Gao Chao*, Enzymatic cascades for efficient biotransformation of racemic lactate derived from corn steep water.ACS Sustainable Chem. Eng. 2017, 5, 3456−3464
8. Ge Yongsheng, Li Kun, Li Lixiang,Gao Chao*, Lijie Zhang, Ma Cuiqing*, Xu Ping, Contracted but effective: production of enantiopure 2,3-butanediol by thermophilic and GRASBacillus licheniformis.Green Chem. 2016, 18, 4693-4703
9. Sheng Binbin, Xu Jing, Ge Yongsheng, Zhang Shuo, Wang Danqi,Gao Chao*, Ma Cuiqing, Xu Ping. Enzymatic resolution by a D-lactate oxidase catalyzed reaction for (S)-2-hydroxycarboxylic acids.ChemCatChem. 2016, 8, 2630 – 2633
10. Gao Chao, Li Zhong, Zhang Lijie, Wang Chao, Li Kun, Ma Cuiqing*, Xu Ping, An artificial enzymatic reaction cascade for a cell-free bio-system based on glycerol,Green Chem. 2015, 17, 804-807
11. Gao Chao, Wang Yujiao, Zhang Yingxin, Lv Min, Dou Peipei, Xu Ping, Ma Cuiqing*, NAD-Independent L-lactate dehydrogenase required for L-lactate utilization in Pseudomonas stutzeriA1501.J. Bacteriol. 2015, 197, 2239–224712.
12. Sheng Binbin, Xu Jing, Zhang Yingxin, Jiang Tianyi, Deng Sisi, Kong Jian,Gao Chao*, Ma Cuiqing, Xu Ping, Utilization of D-lactate as an energy source supports the growth ofGluconobacter oxydans,Appl. Environ. Microbiol. 2015, 81, 4098-4110
获奖情况
2021年山东大学杰出中青年学者
2020年教育部青年长江学者
2019年山东大学齐鲁青年学者
2018年山东省杰出青年科学基金
2015年山东大学青年学者未来计划
2015年度山东省暨山东大学优秀硕士学位论文指导教师
2020年度山东省暨山东大学优秀硕士学位论文指导教师
所获专利
一株重组大肠杆菌及其在生产2-丁醇中的应用，ZL201510713808.9
一种加速5-氨基戊酸生物法生产的方法，ZL201610628388.9
一种D-乳酸氧化酶及其在D-乳酸检测中的应用，ZL201510135775.4
一株基因工程菌及其在生产(2R,3R)-2,3-丁二醇中的应用，ZL201410314730.9
一种利用L-赖氨酸2-单加氧酶和δ-戊酰胺水解酶催化制备5-氨基戊酸方法，ZL201310241389.4
